Pillow, Thomas: search on Z-Library

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1

Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering

Pillow, Thomas H., Tien, Janet, Parsons-Reponte, Kathryn L., Bhakta, Sunil, Li, Hao, Staben, Leanna R., Li, Guangmin, Chuh, Josefa, Fourie-O’Donohue, Aimee, Darwish, Martine, Yip, Victor, Liu, Luna, L

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 533 KB

english, 2014

2

Antibody Conjugation of a Chimeric BET Degrader Enables In Vivo Activity

Pillow, Thomas H., Adhikari, Pragya, Blake, Robert A., Chen, Jinhua, Del Rosario, Geoffrey, Deshmukh, Gauri, Figueroa, Isabel, Gascoigne, Karen E., Kamath, Amrita V., Kaufman, Susan, Kleinheinz, Tracy

Journal:

Year:

2019

Language:

english

File:

PDF, 1.68 MB

english, 2019

3

Novel linkers and connections for antibody–drug conjugates to treat cancer and infectious disease

Pillow, Thomas H

Journal:

Pharmaceutical Patent Analyst

Year:

2017

Language:

english

File:

PDF, 1.14 MB

english, 2017

4

Front Cover: Antibody Conjugation of a Chimeric BET Degrader Enables inâvivo Activity (ChemMedChem 1/2020)

Pillow, Thomas H., Adhikari, Pragya, Blake, Robert A., Chen, Jinhua, Del Rosario, Geoffrey, Deshmukh, Gauri, Figueroa, Isabel, Gascoigne, Karen E., Kamath, Amrita V., Kaufman, Susan, Kleinheinz, Tracy

Journal:

Year:

2020

File:

PDF, 443 KB

2020

5

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes

Hewings, David S., Heideker, Johanna, Ma, Taylur P., AhYoung, Andrew P., El Oualid, Farid, Amore, Alessia, Costakes, Gregory T., Kirchhofer, Daniel, Brasher, Bradley, Pillow, Thomas, Popovych, Nataliy

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 3.18 MB

english, 2018

6

The cryptophycins as potent payloads for antibody drug conjugates

Verma, Vishal A., Pillow, Thomas H., DePalatis, Laura, Li, Guangmin, Phillips, Gail Lewis, Polson, Andrew G., Raab, Helga E., Spencer, Susan, Zheng, Bing

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 459 KB

english, 2015

7

SAT and ACT predict college GPA after removing g

Thomas R. Coyle, David R. Pillow

Journal:

Year:

2008

Language:

english

File:

PDF, 606 KB

english, 2008

8

The importance of cognitive diversity for sustaining the commons

Baggio, Jacopo A., Freeman, Jacob, Coyle, Thomas R., Nguyen, Tam The, Hancock, Dale, Elpers, Karrie E., Nabity, Samantha, Dengah II, H. J. Francois, Pillow, David

Journal:

Nature Communications

Year:

2019

Language:

english

File:

PDF, 966 KB

english, 2019

9

Function-Oriented Synthesis, Step Economy, and Drug Design

Wender, Paul A., Verma, Vishal A., Paxton, Thomas J., Pillow, Thomas H.

Journal:

Accounts of Chemical Research

Year:

2008

Language:

english

File:

PDF, 1.80 MB

english, 2008

10

Carfilzomib is not an appropriate payload of antibody-drug conjugates due to rapid inactivation by lysosomal enzymes

Ma, Yong, Cruz-Chuh, Josefa Dela, Khojasteh, S Cyrus, Dragovich, Peter S, Pillow, Thomas H, Zhang, Donglu

Journal:

Drug Metabolism and Disposition

Year:

2019

Language:

english

File:

PDF, 1.10 MB

english, 2019

11

Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

Lehar, Sophie M., Pillow, Thomas, Xu, Min, Staben, Leanna, Kajihara, Kimberly K., Vandlen, Richard, DePalatis, Laura, Raab, Helga, Hazenbos, Wouter L., Hiroshi Morisaki, J., Kim, Janice, Park, Summer,

Journal:

Year:

2015

Language:

english

File:

PDF, 2.22 MB

english, 2015

12

Cathepsin B is dispensable for cellular processing of cathepsin B-cleavable antibody-drug conjugates

Caculitan, Niña G., dela Cruz Chuh, Josefa, Ma, Yong, Zhang, Donglu, Kozak, Katherine R, Liu, Yichin, Pillow, Thomas H., Sadowsky, Jack, Cheung, Tommy K, Phung, Qui, Haley, Benjamin, Lee, Byoung-Chul,

Journal:

Cancer Research

Year:

2017

Language:

english

File:

PDF, 2.91 MB

english, 2017

13

Treatment of bone-marrow failure by isogenic marrow infusion

Pillow, R. P., Epstein, R. B., Buckner, C. D., Giblett, E. R., Thomas, E. D.

Journal:

Transplantation Journal

Year:

1967

File:

PDF, 69 KB

1967

14

Molecular Transporters: Synthesis of Oligoguanidinium Transporters and Their Application to Drug Delivery and Real-Time Imaging

Elena A. Goun, Thomas H. Pillow, Lisa R. Jones, Jonathan B. Rothbard, Paul A. Wender

Journal:

Year:

2006

Language:

english

File:

PDF, 790 KB

english, 2006

15

Potent and Sustained Activity of Novel THIOMAB™ Antibiotic Conjugate (TAC) Against Staphylococcus aureus as Measured by Bioluminescence Imaging

Zhou, Chenguang, Baruch, Amos, Ramanujan, Saroja, Pillow, Thomas, Yang, Meng, Guo, Fengxun, Xu, Deming, Kamath, Amrita

Journal:

Open Forum Infectious Diseases

Year:

2016

Language:

english

File:

PDF, 158 KB

english, 2016

16

Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Non-Cleavable Drug-Linkers

Gregson, Stephen J., Masterson, Luke A., Wei, Binqing, Pillow, Thomas H., Spencer, Susan D., Kang, Gyoung-Dong, Yu, Shang-Fan, Raab, Helga, Lau, Jeffrey, Li, Guangmin, Lewis Phillips, Gail D., Gunzner

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.69 MB

english, 2017

17

SAT predicts GPA better for high ability subjects: Implications for Spearman’s Law of Diminishing Returns

Thomas Coyle, Anissa Snyder, David Pillow, Peter Kochunov

Journal:

Personality and Individual Differences

Year:

2011

Language:

english

File:

PDF, 185 KB

english, 2011

18

Epidemiologic study of asymptomatic men screened by maximal treadmill testing for latent coronary artery disease

Victor F. Froelicher Jr., Mary M. Thomas, Charles Pillow, Malcolm C. Lancaster

Journal:

The American Journal of Cardiology

Year:

1974

Language:

english

File:

PDF, 839 KB

english, 1974

19

Unintended adverse consequences of electronic health record introduction to a mature universal HIV screening program

Medford-Davis, Laura N., Yang, Katharine, Pasalar, Siavash, Pillow, M. Tyson, Miertschin, Nancy P., Peacock, William F., Giordano, Thomas P., Hoxhaj, Shkelzen

Journal:

Year:

2016

Language:

english

File:

PDF, 1.54 MB

english, 2016

20

Cortical sulci and bipolar disorder

Coyle, Thomas R., Kochunov, Peter, Patel, Rupal D., Nery, Fabiano G., Lancaster, Jack L., Mangin, Jean-Fran??ois, Rivi??re, Denis, Pillow, David R., Davis, Gregory J., Nicoletti, Mark A., Serap Monkul

Journal:

Year:

2006

Language:

english

File:

PDF, 85 KB

english, 2006

21

Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody–Drug Conjugates with Self-Immolative Disulfide Linkers

Pillow, Thomas H., Schutten, Melissa, Yu, Shang-Fan, Ohri, Rachana, Sadowsky, Jack, Poon, Kirsten Achilles, Solis, Willy, Zhong, Fiona, Del Rosario, Geoffrey, Go, Mary Ann T., Lau, Jeffrey, Yee, Sharo

Journal:

Molecular Cancer Therapeutics

Year:

2017

Language:

english

File:

PDF, 711 KB

english, 2017

22

Design, Synthesis, and Biological Evaluation of Pyrrolobenzodiazepine-containing Hypoxia-activated Prodrugs

Dragovich, Peter S., Broccatelli, Fabio, Chen, Jinhua, Fan, Peter, Le, Hoa, Mao, Weiguang, Pillow, Thomas H., Polson, Andrew G., Wai, John, Xu, Zijin, Yao, Hui, Zhang, Donglu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 435 KB

english, 2017

23

Intratumoral Payload Concentration Correlates with the Activity of Antibody- Drug Conjugates

Zhang, Donglu, Yu, Shang-Fan, Khojasteh, S Cyrus, Ma, Yong, Pillow, Thomas H., Sadowsky, Jack D, Su, Dian, Kozak, Katherine R, Xu, Keyang, Polson, Andrew G, Dragovich, Peter, Hop, Cornelis ECA

Journal:

Molecular Cancer Therapeutics

Year:

2018

Language:

english

File:

PDF, 2.05 MB

english, 2018

24

The design of guanidinium-rich transporters and their internalization mechanisms

Paul A. Wender, Wesley C. Galliher, Elena A. Goun, Lisa R. Jones, Thomas H. Pillow

Journal:

Advanced Drug Delivery Reviews

Year:

2008

Language:

english

File:

PDF, 1.40 MB

english, 2008

25

Analogues of DNA minor groove cross-linking agents incorporating aminoCBI, an amino derivative of the duocarmycins: synthesis, cytotoxicity, and potential as payloads for antibody-drug conjugates

Giddens, Anna C., Lee, Ho H., Lu, Guo-Liang, Miller, Christian K., Guo, Jun, Lewis Phillips, Gail D., Pillow, Thomas, Tercel, Moana

Journal:

Bioorganic & Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 382 KB

english, 2016

26

High-Resolution Accurate-Mass Mass Spectrometry Enabling In-Depth Characterization of in Vivo Biotransformations for Intact Antibody-Drug Conjugates

He, Jintang, Su, Dian, Ng, Carl, Liu, Luna, Yu, Shang-Fan, Pillow, Thomas H., Del Rosario, Geoffrey, Darwish, Martine, Lee, Byoung-Chul, Ohri, Rachana, Zhou, Hongxiang, Wang, Xueji, Lu, Jiawei, Kaur,

Journal:

Analytical Chemistry

Year:

2017

Language:

english

File:

PDF, 457 KB

english, 2017

27

A novel depurination methodology to assess DNA alkylation of chloro bis-seco-cyclopropylbenzoindoles (CBIs) allowed for comparison of minor groove reactivity

Wang, Shuai, Chen, Buyun, Dragovich, Peter, Pillow, Thomas, Staben, Leanna, Guo, Jun, Su, Dian, Zhang, Chenghong, Bobba, Sudheer, Ma, Yong, Wang, Jianshuang, Sangaraju, Dewakar, Wei, BinQing, Phillips

Journal:

Drug Metabolism and Disposition

Year:

2019

File:

PDF, 636 KB

2019

28

Treatment of Bone-Marrow Failure by Isogeneic Marrow Infusion

Pillow, Randolph P., Epstein, Robert B., Buckner, C. Dean, Giblett, Eloise R., Thomas, E. Donnall

Journal:

Boston Medical and Surgical Journal

Year:

1966

File:

PDF, 582 KB

1966

29

Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates

Pillow, Thomas H., Sadowsky, Jack D., Zhang, Donglu, Yu, Shang-Fan, Del Rosario, Geoffrey, Xu, Keyang, He, Jintang, Bhakta, Sunil, Ohri, Rachana, Kozak, Katherine R., Ha, Edward, Junutula, Jagath R.,

Journal:

Chemical Science

Year:

2016

Language:

english

File:

PDF, 818 KB

english, 2016

30

Development of efficient chemistry to generate site-specific disulfide-linked protein- and peptide-payload conjugates: Application to THIOMAB™ antibody-drug conjugates

Sadowsky, Jack David, Pillow, Thomas H, Chen, Jinhua, Fan, Fang, He, Changrong, Wang, Yanli, Yan, Gang, Yao, Hui, Xu, Zijin, Martin, Shanique, Zhang, Donglu, Chu, Phillip, Cruz-Chuh, Josefa dela, O'Do

Journal:

Bioconjugate Chemistry

Year:

2017

Language:

english

File:

PDF, 6.18 MB

english, 2017

31

Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody–Drug Conjugates

Zhang, Donglu, Pillow, Thomas H., Ma, Yong, Cruz-Chuh, Josefa dela, Kozak, Katherine R., Sadowsky, Jack D., Lewis Phillips, Gail D., Guo, Jun, Darwish, Martine, Fan, Peter, Chen, Jingtian, He, Changro

Journal:

ACS Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 1.02 MB

english, 2016

32

The importance of cognitive diversity for sustaining the commons

Baggio, Jacopo A., Freeman, Jacob, Coyle, Thomas R., Nguyen, Tam The, Hancock, Dale, Elpers, Karrie E., Nabity, Samantha, Dengah II, H. J. Francois, Pillow, David

Journal:

Nature Communications

Year:

2019

File:

PDF, 966 KB

2019

33

Catalytic cleavage of disulfide bonds in small molecules and linkers of antibody- drug conjugates

Zhang, Donglu, Fourie-O'Donohue, Aimee, Dragovich, Peter S, Pillow, Thomas H, Sadowsky, Jack D, Kozak, Katherine R, Cass, Robert T, Liu, Liling, Deng, Yuzhong, Liu, Yichin, Hop, Cornelis ECA, Khojaste

Journal:

Drug Metabolism and Disposition

Year:

2019

Language:

english

File:

PDF, 808 KB

english, 2019

34

Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues

Zhang, Donglu, Dragovich, Peter S., Yu, Shang-Fan, Ma, Yong, Pillow, Thomas H., Sadowsky, Jack D., Su, Dian, Wang, Wei, Polson, Andrew, Khojasteh, S. Cyrus, Hop, Cornelis E.C.A.

Journal:

Drug Metabolism and Disposition

Year:

2019

Language:

english

File:

PDF, 1.15 MB

english, 2019

35

Taxol-oligoarginine conjugates overcome drug resistance in-vitro in human ovarian carcinoma

Paul A. Wender, Wesley C. Galliher, Neelima M. Bhat, Thomas H. Pillow, Marcia M. Bieber, Nelson N.H. Teng

Journal:

Gynecologic Oncology

Year:

2012

Language:

english

File:

PDF, 539 KB

english, 2012

36

Antibody-Drug Conjugates for the Treatment of Cancer

Flygare, John A., Pillow, Thomas H., Aristoff, Paul

Journal:

Chemical Biology & Drug Design

Year:

2013

Language:

english

File:

PDF, 848 KB

english, 2013

37

P49 - Uncovering novel lysosomal pH changes caused by dmDNA31, a novel rifalog payload of an antibody-antibiotic conjugate (AAC) in development to treat staphylococcus aureus infections

Vogt, Jennifer, Hazenbos, Wouter, Pillow, Thomas, Proctor, William

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2020

File:

PDF, 49 KB

2020

38

Chemoselectivity and enantiocontrol in catalytic intramolecular metal carbene reactions of diazo acetates linked to reactive functional groups by naphthalene-1,8-dimethanol

Doyle, Michael P., Ene, Doina G., Forbes, David C., Pillow, Thomas H.

Journal:

Chemical Communications

Year:

1999

Language:

english

File:

PDF, 56 KB

english, 1999

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